Induction of a delayed type hypersensitivity to carrageenin in mice.
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چکیده
منابع مشابه
2088 Induction of Delayed - Type Hypersensitivity
Delayed-type hypersensitivity (DTH) 1 is a T cell-mediated reaction resulting in a mononuclear cell-rich inf lammat ion and swelling that peak 24-48 h after local antigenic challenge. In spite of the extensive use of D T H to dissect regulatory (1), genetic (2), and molecular (3) aspects of in vivo T cell responses, little is known of factors that regulate the persistence o f these reactions. I...
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Mice infected with A/England/939/69 X A/Puerto Rico/8/34 (Rec 31) influenza virus by aerosol develop significantly lower levels of delayed-type hypersensitivity (DTH) to A/Hong Kong/1/68 X A/Puerto Rico/8/34/ (X31) virus compared to uninfected mice. The suppression of DTH to the hemagglutinin appears to be mediated by suppressor T cells which carry Lyt-1 membrane antigen marker, and not by sy s...
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Delayed type hypersensitivity (DTH) is an inflammatory reaction mediated by CCR7- effector memory T lymphocytes that infiltrate the site of injection of an antigen against which the immune system has been primed. The inflammatory reaction is characterized by redness and swelling of the site of antigenic challenge. It is a convenient model to determine the in vivo efficacy of immunosuppressants....
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Mice injected intravenously with 1 X 10(9) sheep red blood cells (SRBC) showed no delayed-type hypersensitivity (DTH) response to SRBC and were unresponsive to DTH induction by sc injection of an optimal dose of SRBC. However, when treated with T-2 toxin, a mycotoxin, 2 days after the iv injection, mice became to show significant DTH response and to be responsive to the DTH induction by the sc ...
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The systemic injection of high doses of antigen into a preimmunized animal results in transient unresponsiveness of cell-mediated immune responses. This phenomenon is known as desensitization. Serum interleukin 2 (IL-2) activity was found transiently in desensitized mice at 3 h after the antigen challenge. These mice could not reveal antigen nonspecific delayed-type hypersensitivity (DTH) 1 d a...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1982
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.5.266